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What is the role of regional organizations in maintaining security across different parts of Latin America and the Caribbean (LAC)? How did COVID-19 impact states in the region and what types of collective action have helped respond to public health emergencies? In what way is LAC environmental policy formulated and what broader lessons can be drawn for the Global South? This edited volume addresses these questions, revealing the reasons behind the successes and failures of LAC regional responses to collective challenges as well as their limitations and potential for future improvement. It contains 11 chapters, authored by 16 authoritative academics who employ methodologically-diverse perspectives. Each chapter provides insights that would be of interest to scholars, students and policy-makers working on the regional governance of LAC and the Global South. The contributions are thematically organised in three parts and produced with pragmatic considerations in mind, discussing existing and potential real solutions to pressing issues.